Figure 5

Ang II–dependent calcium influx in the podocytes is precluded by ATR inhibition. (a) Representative effects of losartan (Los, 10 µM, 30 min incubation) or PD 123319 (PD, 1 µM, 10 min), on Ca²⁺ transients evoked in the podocytes by 10 µM Ang II. (b) Illustrates the lack of an acute effect of a Mas receptor agonist Ang(1–7) on calcium influx in podocytes (concentration applied was 10 µM). (c) Summarized data for the effects of Ang II on calcium influx in the podocytes in the absence or presence of losartan or PD. (i,j) noted on graph is number of animals (i) and podocytes (j) analyzed in each group. *P < 0.01 versus Ang II.