Figure 5 | Scientific Reports

Figure 5

From: Inhibition of serum and glucocorticoid regulated kinase-1 as novel therapy for cardiac arrhythmia disorders

Figure 5

Inhibition with lead compound 5377051 modulates INa by inhibiting SGK1. (A) Addition of 5377051 at 10 uM significantly decreases INa even with co-expression of SGK1-CA. (B) Quantification of changes in peak sodium current with addition of inhibitor 2 (5377051) with and without co-expression of SGK1-CA (n = 4–6 per condition, *p-value < 0.05). (C) Representative time course of inhibition by compound 5377051 as compared to addition of DMSO. (D) Average time for inhibition demonstrating a half-time of 200 s (n = 4).

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