Figure 6
Inhibition of SGK1 in cardiomyocytes selectively reduces the late sodium current INaL. (A) Representative INa from NRVMs at baseline and after acute treatment with compound 5377051 demonstrates preferential reduction of late current. (B) Quantification of the peak current does not demonstrate a significant reduction with administration of the inhibitor (Peak current density: Pre = −560.1 ± 180 pA/pF versus Post = −396.1 ± 230.4 pA/pF). (C) Selective inhibition of native late sodium current with incubation of the lead compound (Late current density: Pre = 5.12 ± 2.4 pA/pF versus Post = −2.3 ± 1.5 pA/pF). (D) Relative decrease in peak to late current ratio. (*p-value < 0.05, †p-value = non-significant, n = 6 for all experiments).
