Figure 4 | Scientific Reports

Figure 4

From: Irreversible inhibition of BTK kinase by a novel highly selective inhibitor CHMFL-BTK-11 suppresses inflammatory response in rheumatoid arthritis model

Figure 4

CHMFL-BTK-11 inhibits synovial cells and B cells proliferation and ameliorates total serum antibody production in AA rat model. (a) CHMFL-BTK-11 inhibits the synovial cells proliferation from AA rats. (b) CHMFL-BTK-11 inhibits B cells proliferation induced by LPS from AA rats. (c) Antibodies assay (IgG1, IgG2a, and IgM) from AA rats after drug administration. (d) Serum IL-6 and IL-10 measurement from AA rats after drug administration. (e) CHMFL-BTK-11 reduced the peritoneal macrophages (PMΦ) phagocytosis from AA rats. (f) The inhibitory effects of CHMFL-BTK-11 on proliferation of rat B cells. CHMFL-BTK-12, PCI-32765, or MTX were set as controls. Student’s t-test was used and data were representative of at least 2 independent experiments. ns, P > 0.05, *P < 0.05, **P < 0.01.

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