Figure 5
β-diversity in stool microbiota of WT HFD, Nod2 −/− HFD, WT LFD, and Nod2 −/− LFD mice. (a) Principal Coordinate Analysis (PCoA) by UniFrac (unweighted) of microbiomes. Each sphere with confidence elipsoid corresponds to a stool microbiome from one mouse. N = 6 mice/group. (b) Class abundance expressed as % of total stool microbiota; *classes with significantly (at P ≤ 0.05) increased abundance in WT versus Nod2 −/− mice (on HFD or LFD); #classes with significantly (at P ≤ 0.05) increased abundance in HFD versus LFD groups (for WT or Nod2 −/− mice); N = 6 mice/group. The results for individual mice are shown in Supplementary Fig. S4. The entire microbiome analysis data comparing bacterial diversity in the stools of WT and Nod2 −/− mice maintained on HFD and LFD have been deposited in NCBI SRA, accession No. SRP076031.
