Figure 5 | Scientific Reports

Figure 5

From: Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus

Figure 5

Effects of Xiaoyaosan on the JAK2-STAT3 signalling pathway in the rat hippocampus. (A) Expression of the p-JAK2 protein in the rat hippocampus. (B) Total JAK2 levels in the rat hippocampus. (C) Expression of the STAT3 protein in the rat hippocampus. (D) Expression of the JAK2 mRNA in the rat hippocampus. (E) Expression of the STAT3 mRNA in the rat hippocampus. Values are presented as the means ± SEM from 3–4 rats per group for determination of the expression of the p-JAK2 and STAT3 proteins, from 6 rats per group for the determination of total JAK2 levels, and from 5 rats per group for the determination of the expression of JAK2 and STAT3 mRNA in the rat hippocampus. *P < 0.05 or **P < 0.01 versus the control group. Δ P < 0.05 or ΔΔ P < 0.01 versus the vehicle (distilled water) group. # P < 0.05 or ## P < 0.01 versus the vehicle (dissolvent) group.

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