Figure 4
From: Clinically applicable GABA receptor positive allosteric modulators promote ß-cell replication
Treatment with bicuculline ablates the ability of alprazolam to enhance islet cell replication. Human islets were incubated with alprazolam (100 nM) together with a standard dose range of bicuculline (0–50 uM). Data shown are the average rate of proliferation relative to that of cultures with medium alone (designated as 1).
