Figure 1 | Scientific Reports

Figure 1

From: Identification of small molecule inhibitors of Interleukin-18

Figure 1

Human IL-18 Viral and Ternary Receptor Complex Crystal Structures. (A) Crystal structure of hIL-18:ectvIL-18BP viral complex, PDB entry 3F62. Depicted in ribbon diagram and colored in light yellow is ectvIL-18BP, hIL-18 is drawn in surface representation. Residues of ectvIL-18BP at the interface are shown as sticks, interacting with previously identified binding sites on hIL-18 colored as site A (red), site B (orange), and site C (cyan). The remaining surface of hIL-18 is colored in grey. (B) Crystal structure of hIL-18 ternary receptor complex, PDB entry 3WO4. Drawn as cartoon representation and colored green and magenta are hIL-18 Receptor α and β, respectively. Human IL-18 has been drawn as seen in panel A.

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