Figure 1
From: The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity
G2A-deficient mice have reduced oxaliplatin-induced mechanical pain thresholds. (A) Mechanical pain thresholds of mice after i.p.-injection of oxaliplatin (3 mg/kg) compared to vehicle (0.9% v/v DMSO) using a dynamic plantar aesthesiometer over ten days. Shown is the mean ± SEM of paw withdrawal latency (PWL) of n = 8 mice per group. (B) Mechanical pain thresholds of wildtype (WT) compared to G2A-deficient mice after treatment with oxaliplatin (3 mg/kg) using a dynamic plantar aesthesiometer over ten days. Shown is the mean ± SEM of PWL of n = 8 mice per group; *p < 0.05 **p < 0.01 ***p < 0.001 two-way ANOVA with Bonferroni post-hoc test.
