Table 3 Clinicopathological characteristics of the samples with concurrent mutations in the four genomic subtypes.

No.	Gender	Age	Breslow (mm)	Anatomic site	Sun related site	Histological subtype	Gene	Amino acid change	Allele frequency (%)
2	M	79	2.7	Trunk	Occasional exposed	SSM	BRAF	p.Gly464Arg	6.8
2	M	79	2.7	Trunk	Occasional exposed	SSM	NF1	p.Arg711Cys	4.7
28	F	58	0.7	Lower extremities	Occasional exposed	SSM	NRAS	p.Glu62Gln	8.0
28	F	58	0.7	Lower extremities	Occasional exposed	SSM	NRAS	p.Gln61Arg	8.0
58	M	69	0.4	Trunk	Occasional exposed	SSM	BRAF	p.Leu597Arg	4.1
58	M	69	0.4	Trunk	Occasional exposed	SSM	NRAS	p.Gly12Ser	5.0
62	M	66	4.2	Head and neck	Usually exposed	LMM	KRAS	p.Gly12Val	80.8
62	M	66	4.2	Head and neck	Usually exposed	LMM	NF1	p.Trp1512*	30.8
68	M	54	0.7	Head and neck	Usually exposed	SSM	BRAF	p.Val600Glu	25.4
68	M	54	0.7	Head and neck	Usually exposed	SSM	NF1	p.Lys1844Th	6.3
71	F	85	3	Acral	Non exposed	ALM	KIT	p.Tyr553Ser	31.8
71	F	85	3	Acral	Non exposed	ALM	KIT	p.Tyr578Cys	43.9
80	F	73	0.3	Upper extremities	Occasional exposed	SSM	BRAF	p.Val600Glu	2.0
80	F	73	0.3	Upper extremities	Occasional exposed	SSM	NRAS	p.Gln61Arg	3.0
84	F	57	2	Upper extremities	Occasional exposed	SSM	BRAF	p.Leu584Phe	23.1
84	F	57	2	Upper extremities	Occasional exposed	SSM	NRAS	p.Gln61Leu	24.0
107	M	59	6	Head and neck	Usually exposed	NM	KRAS	p.Gln61Arg	5.3
							KRAS	p.Ala146Val	10.6
							NF1	p.Gln1070*	13.5

M: Male; F: Female; SSM: Superficial spreading melanoma; LM: Lentigo Maligna; NM: Nodular melanoma; ALM: Acral lentiginous melanoma.

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