Table 1 Characteristics of study participants.

From: Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease

 

Low NAL

High NAL

p

Gender (M/F)

19/46

13/22

0.419

Age (years, mean ± SD)

77.61 ± 5.55

79.22 ± 5.38

0.165

BMI (mean ± SD)

27.38 ± 4.47

28.05 ± 4.73

0.486

Education (years, mean ± SD)

14.86 ± 3.31

13.66 ± 2.84

0.078

Total cholesterol (mmol/L, mean ± SD)

4.82 ± 0.98

4.35 ± 1.19

0.045

Triglycerides (mmol/L, mean ± SD)

1.34 ± 0.70

1.10 ± 0.42

0.071

HDL cholesterol (mmol/L, mean ± SD)

1.64 ± 0.55

1.52 ± 0.48

0.292

LDL cholesterol (mmol/L, mean ± SD)

2.39 ± 0.85

2.34 ± 0.88

0.794

Testosterone (nmol/L, mean ± SD), males

14.43 ± 6.16

11.66 ± 3.77

0.160

Testosterone (nmol/L, mean ± SD), females

1.45 ± 2.55

1.26 ± 0.81

0.738

Oestradiol (pmol/L, mean ± SD), males

113.16 ± 47.83

117.23 ± 35.17

0.795

Oestradiol (pmol/L, mean ± SD), females

91.22 ± 118.71

73.90 ± 28.97

0.523

APOE ε4 carriers (%)

7.69

45.71

0.00000848

MMSE (mean ± SD)

28.50 ± 1.16

28.80 ± 1.10

0.225

FBB-PET SUVR (mean ± SD)

1.15 ± 0.08

1.71 ± 0.26

—

HV% (left; right lobes, mean ± SD)

0.195 ± 0.020; 0.199 ± 0.021

0.194 ± 0.019; 0.199 ± 0.018

0.805; 0.890

  1. Baseline characteristics including gender, age, body mass index (BMI), education, serum cholesterol, hormone levels, APOE ε4 status, mini mental state examination (MMSE) scores, neocortical amyloid load (NAL) represented by the standard uptake value ratio (SUVR) of the ligand 18F-Florbetaben (FBB) in the neocortical region normalised with that in the cerebellum and hippocampal volume (HV) normalised by the intracranial volume, have been compared between study participants with low NAL (SUVR < 1.35) and high NAL (SUVR ≥ 1.35). Chi-square test or linear models were employed as appropriate. HDL: high density lipoprotein, LDL: low density lipoprotein.
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