Table 2 Erythrocyte fatty acid concentrations in low and high NAL.

From: Alterations in erythrocyte fatty acid composition in preclinical Alzheimer’s disease

 

Low NAL (mean ± SD)

High NAL (mean ± SD)

p

pa

pb

SFA

C14:0 (Myristic acid)

0.40 ± 0.07

0.38 ± 0.06

0.184

0.335

0.364

C16:0 (Palmitic acid)

21.94 ± 1.40

21.67 ± 0.85

†0.374

†0.576

†0.610

C18:0 (Stearic acid)

15.70 ± 1.03

16.05 ± 0.80

0.088

0.062

0.080

C20:0 (Arachidic acid)

0.40 ± 0.07

0.42 ± 0.06

0.196

0.128

0.157

C24:0 (Lignoceric acid)

5.03 ± 2.29

4.77 ± 0.84

0.520

0.217

0.236

Total SFA

43.49 ± 0.87

43.31 ± 1.21

0.392

0.157

0.157

MUFA

C14:1 (Myristoleic acid)

0.01 ± 0.00

0.01 ± 0.01

0.171

0.306

0.313

C16:1 (Palmitoleic acid)

0.34 ± 0.13

0.30 ± 0.08

†0.345

†0.265

†0.239

C18:1n-9 (Oleic acid)

8.74 ± 0.71

8.77 ± 0.64

0.824

0.946

0.887

C18:1n-7 (Vaccenic acid)

1.91 ± 0.43

2.02 ± 0.61

†0.385

†0.865

†0.787

C20:1n-9 (Eicosenoic acid)

0.25 ± 0.05

0.26 ± 0.07

†0.578

†0.231

†0.246

C24:1 (Nervonic acid)

4.92 ± 0.92

5.06 ± 0.89

0.478

0.841

0.831

Total MUFA

16.19 ± 1.25

16.45 ± 1.38

0.334

0.939

0.921

n-6 PUFA

C18:2n-6 (Linoleic acid)

8.82 ± 1.41

8.23 ± 1.48

0.052

0.878

0.924

C18:3n-6 (γ-Linolenic acid)

0.77 ± 0.73

1.08 ± 1.64

†0.928

†0.244

†0.281

C20:2n-6 (Eicosadienoic acid)

0.14 ± 0.04

0.13 ± 0.04

0.300

0.717

0.668

C20:3n-6 (Dihomo-γ-linolenic acid)

1.60 ± 0.46

1.66 ± 0.41

0.586

0.237

0.301

C20:4n-6 (Arachidonic acid)

15.70 ± 2.12

16.72 ± 1.91

0.020

0.035

0.043

Total omega-6

27.07 ± 2.62

27.84 ± 2.29

0.145

0.023

0.027

n-3 PUFA

C18:3n-3 (Linolenic acid)

0.16 ± 0.10

0.12 ± 0.07

0.033

0.076

0.084

C20:5n-3 (Eicosapentaenoic acid)

1.72 ± 0.96

1.42 ± 0.69

0.106

0.063

0.068

C22:5n-3 (Docosapentaenoic acid)

3.33 ± 0.64

3.15 ± 0.50

0.143

0.027

0.025

C22:6n-3 (Docosahexaenoic acid)

8.01 ± 1.59

7.68 ± 1.40

0.308

0.458

0.512

Total omega-3

13.24 ± 2.72

12.38 ± 2.20

0.111

0.100

0.116

Omega-3 Index

9.73 ± 2.32

9.10 ± 1.96

0.176

0.337

0.233

  1. Using linear models, fatty acid concentrations were compared between study participants with low (N = 65) and high (N = 35) neocortical amyloid load (NAL) represented by the standard uptake value ratio (SUVR) of the ligand 18F-Florbetaben in the neocortical region normalised with that in the cerebellum. Low NAL was defined as SUVR < 1.35 while high NAL was defined as SUVR ≥ 1.35. pa indicates p values adjusted for age, gender, years of education and APOE ε4 status; pb indicates p values adjusted age, gender, years of education, APOE ε4 status, body mass index, fatty acid supplement intake (cod liver oil, flaxseed oil), hormone replacement therapy. ‘†’ indicates p-values obtained from variables transformed to the logarithmic scale for analyses. SFA: saturated fatty acids; MUFA: monounsaturated fatty acids; PUFA: polyunsaturated fatty acids; omega-3 index: sum of eicosapentaenoic acid and docosahexaenoic acid, expressed as a percentage of total erythrocyte fatty acid measured.
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