Figure 5 | Scientific Reports

Figure 5

From: Systematic Synergy of Glucose and GLP-1 to Stimulate Insulin Secretion Revealed by Quantitative Phosphoproteomics

Figure 5

Synergistic regulation of secretion pathway. Regulated proteins annotated by GO database matching the biological process terms “insulin secretion” or “exocytosis” were presented to clarify the synergistic effect mediated by glucose and GLP-1 in secretion pathway. Only proteins with phosphorylation sites regulated by GLP-1 (LGLP1), glucose (HGlc) or their synergism (HGLP1) with high confidence were taken into count. The regulated sites were color-coded according to different regulation pattern as defined in Fig. 1G. Sold line means reported kinase-substrate relationship.

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