Figure 6
β-cell kinome regulated by GLP-1 and glucose. Regulated kinases were ordered by phylogenetic distance of the kinase domain retrieved from KinBase (mouse ortholog), and displayed using iTOL (see Methods for details). The phosphorylation change of each regulated sites on each kinase induced by different treatments were presented using heatmap in the outer rim. In the middle rim, the activation or inhibition status of regulated kinases were determined by the direction and amplitude of change of reported activation or inhibitory sites. The biological process that these kinases involved in were annotated according to GO database, and displayed in the inner rim. All proteins were listed by their corresponding gene names used by KinBase.
