Figure 3
From: Elevated levels of Wnt signaling disrupt thymus morphogenesis and function
TEC-intrinsic β-catenin overexpression disrupts thymus and parathyroid development. (A) Development of the parathyroid and thymus of wild-type mice at E15.5 examined by H&E staining and RNA in situ hybridization with the indicated gene-specific probes. (B) Development of the parathyroid and thymus of mutant mice at E15.5 examined as in (A). (C) Development of the parathyroid and thymus of mutant mice at E15.5 examined as in (A); sections are derived from the same embryo, with the top row depicting the ectopic location of the left parathyroid lobe and the thymic lobes (approximately at the level of the pharyngeal inlet), and the second row demonstrating the position of the right parathyroid in the expected position at the anterior pole of the thyroid. The numerical figure label key applies to all figures. In (A–C), H&E stained sections are matched with corresponding sections subjected to RNA in situ hybridization. (D) RNA in situ hybridization with a GrzA probe to detect developing thymocytes.
