Figure 6
From: Elevated levels of Wnt signaling disrupt thymus morphogenesis and function
Deficiency in β-catenin or Nlk fails to correct defective organ migration induced by Wnt4-overexpression. (A) Immunohistochemistry analysis of E15.5 β-catenin-sufficient (top row) and Ctnnb1-deficient (bottom row) Foxn1::Wnt4-transgenic embryos. (B) Development of thyroid, thymus and parathyroid in E15.5 Nlk-sufficient (left panels) and Nlk-deficient (right panels) Foxn1::Wnt4-transgenic embryos analyzed as in Fig. 5A. (C) Ectopic thyroid tissue in the septum of the tongue identified by H&E staining and RNA in situ hybridization with a Titf1 probe. Ectopic thyroid tissue located ventral to the trachea can also be observed in (B), second to top panel in the left column, bottom panel in the right column.
