Table 11 Total propensities obtained in four steady state conditions according to folate polymorphism (CC and TT case) and total concentration of available folate (replete, 18 µM; low, 9 µM).

From: A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis

a 0(x)

replete folate

low folate

Difference (% of replete folate)

CC

1.6054 · 1015

2.0970 · 1015

30.62

TT

8.5915 · 1015

1.0141 · 1016

18.03

Difference (% of CC)

435.15

383.59

 
  1. To help comparisons, the differences between CC and TT (in % of CC) and between replete and low total folate (in % of replete folate) are indicated. A steady state that is less stable (or more noisy) than another one has higher total propensity.
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