Table 2 Concentrations of model variables (in µM) for different levels of MTHFR activity (ranging from 2x to 0.3x of wild type). CC, CT and TT refer to the C667T polymorphism.
µM | THF | 10fTHF | CHF | CH2F | DHF | 5 mTHF | Unbound SHMT | HCY | MET | SAM | SAH | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
free | bound | total | |||||||||||
MTHFR x2 | 0.04 | 2.58 | 0.51 | 0.14 | 0.00 | 5.97 | 8.60 | 14.57 | 0.40 | 3.10 | 37.99 | 78.41 | 31.01 |
MTHFR x1 – CC | 0.12 | 7.00 | 1.37 | 0.34 | 0.01 | 1.44 | 7.56 | 9.00 | 1.44 | 3.47 | 42.44 | 51.34 | 53.26 |
MTHFR x0.7 – CT | 0.28 | 8.70 | 1.69 | 0.39 | 0.01 | 0.60 | 6.18 | 6.78 | 2.82 | 3.67 | 43.00 | 34.87 | 68.98 |
MTHFR x0.5 | 0.56 | 9.73 | 1.88 | 0.41 | 0.01 | 0.33 | 4.93 | 5.26 | 4.07 | 3.78 | 42.59 | 26.72 | 77.42 |
MTHFR x0.3 – TT | 1.45 | 10.48 | 2.01 | 0.43 | 0.01 | 0.16 | 3.31 | 3.47 | 5.69 | 3.89 | 41.87 | 20.47 | 84.29 |
