Table 7 Concentrations of model variables (in µM) for replete (18 µM) and low (9 µM) levels of total folate and for the CC and TT case of the C667T MTHFR polymorphism.

From: A hybrid stochastic model of folate-mediated one-carbon metabolism: Effect of the common C677T MTHFR variant on de novo thymidylate biosynthesis

μM

 

THF

10fTHF

CHF

CH2F

DHF

5 mTHF

Free SHMT

HCY

MET

SAM

SAH

free

bound

total

low folate

CC

0.11

3.43

0.67

0.15

0.00

0.44

4.12

4.56

2.55

3.73

42.84

30.34

73.61

TT

0.38

4.44

0.84

0.15

0.00

0.08

3.03

3.11

10.00

3.95

41.35

17.43

87.79

replete folate

CC

0.12

7.00

1.37

0.34

0.01

1.44

7.56

9.00

1.44

3.47

42.44

51.34

53.26

TT

1.45

10.48

2.01

0.43

0.01

0.16

3.31

3.47

5.69

3.89

41.87

20.47

84.29

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