Figure 1 | Scientific Reports

Figure 1

From: Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide

Figure 1

GDF15 deficiency exacerbates cardiac and renal injury after LPS administration. WT, GDF15 TG and GDF15 KO mice were i.p. injected with 4 mg/kg of LPS (WT + LPS, TG + LPS and KO + LPS group) or PBS (WT, TG and KO group) for 16 hours. Blood was collected to measure concentrations of BUN (A) and serum creatinine (B) to assess renal function Ultrasound scanning was performed to measure EF% (C) and FS% (D) for heart function. After ultrasound scanning, mice were sacrificed. n = 9–10 for mice treated with LPS and n = 4/group for PBS injected groups in Fig. 1(A,B); n = 5 for (C,D); *P ≤ 0.05, **P ≤ 0.01. a: WT + LPS vs. either WT, TG or KO group; b: TG + LPS vs. either WT, TG or KO group; c: KO + LPS vs. either WT, TG or KO group.

Back to article page