Figure 6 | Scientific Reports

Figure 6

From: Growth Differentiation Factor-15 Deficiency Augments Inflammatory Response and Exacerbates Septic Heart and Renal Injury Induced by Lipopolysaccharide

Figure 6

Prior treatment with rhGDF15 reduces the amount of early apoptotic cells seen 4 hours after LPS treatment. Primary kidney tubular cells and primary cardiomyocytes from WT mice were cultured and treated with 25 µg/ml LPS alone for 4 hs, rhGDF15 two hours prior to LPS treatment or were untreated. Cells were then collected, stained with Annexin V and PI and detected using flow cytometry. Representative dot plots are shown for each treatment group (A). Summarized data for kidney cells are shown in (B) and for heart cells in (C). Data are representative of 3 independent experiments; *P ≤ 0.05.

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