Figure 1 | Scientific Reports

Figure 1

From: LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway

Figure 1

Low frequency magnetic fields inhibit tumor growth in a Lewis lung cancer murine model. C57BL/6 mice (n = 12 each group) subcutaneously inoculated with lewis lung cancer cells (5 × 105) were exposed to LF-MF (0.4T, 7.5 Hz) or Sham MF for 35 days (2 h per day). (A) Representative images of LLC tumors after treatment of MF or Sham MF. (B) Growth curve of LLC tumors was calculated during treatment of MF or Sham MF. (C) Representative images of hematoxylin and eosin staining (10×) of tumors. (D) Survival curve of mice was calculated during treatment of MF or Sham MF. (E,F) Representative images of immunohistochemical (IHC) staining for Ki-67. Scale bars, 100 µm. (F) Positive cells of Ki-67 were counted using Image Pro Plus software 6.0. Data represent one of two independent experiments. Data represent Mean ± SEM. *P < 0.05, **P < 0.01 and ***P < 0.001.

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