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Figure 1

From: Moderate lifelong overexpression of tuberous sclerosis complex 1 (TSC1) improves health and survival in mice

Figure 1

Generation of Tsc1 tg mice. (a) Diagram of DNA construct used for generating hTSC1 transgenic mice. pUbC: ubiquitin C promoter. (b) Detection of hTSC1 transgene by PCR using genomic DNA isolated from the tail of one of the founder lines. Tg – hTSC1 transgenic founder #1; WT – wild type pups; (+) – positive control DNA for hTSC1. (c) Quantification of TSC1 protein expression in different tissues of Tsc1 tg mice using western blot (n = 6 mice/group). B – brain; L – liver; H – heart; K – kidney; M – skeletal muscle. The asterisks indicate statistical significance between Tsc1 tg and wild type mice (*p < 0.05).

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