Figure 5

Glucose tolerance and insulin sensitivity in TSC1 tg mice. (a) Glucose tolerance test (GTT) in 22–24 month old female mice (n = 6 mice in each group). (b) Insulin sensitivity test (ITT) in female 22–24 month old mice (n = 6 mice in each group). Blood glucose was measured every 15 or 30 minutes after either glucose or insulin injection. The left graphs corresponding to each graph on the left are plotted after normalizing to the levels of blood glucose just prior to the injection. WT – wild type mice (white square); TSC1 - TSC1 tg mice (Solid black circle).