Figure 3

Inflammatory mediators profiling of CD8⁺ T cell in RA patients. (a) The figure represents fold increase in the relative mRNA expression, calculated with respect to β-actin, for Granzyme B, Perforin, TNFα and IFNγ in CD8⁺ T cells isolated from RA patients (n = 23) and HC samples (n = 23). (b) Bar graph shows percentage of Granzyme B, Perforin, TNFα and IFNγ expressing CD3⁺CD8⁺ T cells in rheumatoid arthritis (RA, n = 5) and healthy control (HC, n = 4) samples. (c) Bar graph represents CD8⁺ T cell subpopulations and a co-expression of TLR4 and Granzyme B proteins (n = 5, RA and n = 4, HC). Bars represent the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001.