Figure 2
From: AMPK signaling in the nucleus accumbens core mediates cue-induced reinstatement of cocaine seeking
Activation of AMPK activity in the NAc core decreased the cue-induced reinstatement of cocaine seeking and inhibited mTORC1 and ERK1/2 signaling. (A) The number of self-infusions during daily 3-h sessions increased in the cocaine self-administration groups (n = 9 per group). (B) Responding during daily 3-h extinction sessions decreased in the cocaine groups. (C,D) Average active or inactive nosepoke responding during a 30-min cue-induced reinstatement session before which the rats received intra-NAc core infusions of vehicle or AICAR (2.5 or 7.5 μg/side). (E,F) Percentage of phosphorylated AMPK, phosphorylated p70s6k, phosphorylated ERK1/2, total AMPK, total p70s6k, and total ERK1/2 in the NAc core and shell relative to the vehicle group and representative Western blots (n = 9 per group). The data are expressed as mean ± SEM. *p < 0.05, compared with vehicle group.
