Figure 3 | Scientific Reports

Figure 3

From: Inhibition of late sodium current suppresses calcium-related ventricular arrhythmias by reducing the phosphorylation of CaMK-II and sodium channel expressions

Figure 3

TTX and eleclazine (Elec) abolished ventricular arrhythmias induced by Bay K 8644 both in absence (a) and presence (b) of ATX-II. Representative recordings of MAPs (upper records in each panel) and ECG (lower records in each panel) were recorded simultaneously in control, Bay K 8644 (200 and 300 nM, a) or ATX-II-treated hearts (b) before and after treatment with TTX. Arrows indicate an episode of VT. The incidence of all ventricular arrhythmias and VT are presented in panel c. * P < 0.05 vs. ctrl; # P < 0.05 vs. Bay K 8644; † P < 0.05 vs. ATX-II; & P < 0.05 vs. ATX-II plus Bay K 8644.

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