Table 4 Univariate and multivariate logistic regression analysis of prognostic factors for clinical treatment failure*.
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
Odds ratio | 95% CI | P value | Odds ratio | 95% CI | P value# | |
Patient category | ||||||
Neonates | 1.20 | 0.75–1.91 | 0.451 | |||
Children | 1.0 | (reference) | ||||
Underlying chronic comorbidities | ||||||
Renal sufficiency with/without dialysis | 3.11 | 1.53–6.33 | 0.002 | 1.99 | 0.86–4.60 | 0.109 |
Hematological/Oncological malignancy | 1.42 | 0.75–2.67 | 0.284 | |||
Septic shock | 6.96 | 3.97–12.22 | <0.001 | 5.49 | 2.85–10.57 | <0.001 |
Delayed CVC removal (>72 hours) | 6.40 | 3.69–11.07 | <0.001 | 5.52 | 2.97–10.25 | <0.001 |
Breakthrough candidemia | 5.27 | 2.55–10.87 | <0.001 | 3.66 | 1.43–9.35 | 0.007 |
Initial inadequate antifungal agents (first 24 hours) | 1.32 | 0.81–2.18 | 0.275 | |||
Delayed initiation of effective antifungal agents (48 hours) | 1.78 | 1.13–2.82 | 0.014 | 1.14 | 0.61–2.13 | 0.673 |
Initial antifungal therapy | ||||||
Fluconazole/Voriconazole | 1.0 | (reference) | ||||
Amphotericin B | 0.682 | 0.41–1.15 | 0.147 | |||
Echinocandin-based regimen | 0.908 | 0.30–2.71 | 0.862 | |||
Pathogens | ||||||
Candida albicans | 1 | (reference) | 1 | (reference) | ||
Non-albicans Candida spp. | 1.72 | 1.09–2.71 | 0.021 | 1.42 | 0.78–2.57 | 0.254 |
Uncommon Candida spp.** | 1.85 | 0.98–3.49 | 0.059 | 1.50 | 0.66–3.39 | 0.330 |
Case years | ||||||
2003–2006 | 0.665 | 0.38–1.15 | 0.148 | |||
2007–2011 | 0.664 | 0.38–1.16 | 0.152 | |||
2012–2015 | 1 | (reference) | ||||
