Table 5 Multivariate logistic regression analysis for fungemia-attributable mortality and final in-hospital mortality in children with Candida bloodstream infection.
Variables | Fungemia attributable mortality (total episodes = 310, mortality n = 66) | Final in-hospital mortality* (total patients = 253, mortality n = 83) | ||||
|---|---|---|---|---|---|---|
Odds ratio | 95% CI | P value# | Odds ratio | 95% CI | P value# | |
Patient category | ||||||
Neonates | 2.87 | 1.16–3.43 | 0.013 | 2.76 | 1.23–6.20 | 0.014 |
Children | 1 | (reference) | 1 | (reference) | ||
Underlying chronic comorbidities | ||||||
Renal sufficiency with/without dialysis | 2.48 | 0.89–6.92 | 0.081 | 4.69 | 1.60–13.75 | 0.005 |
Hematological/Oncological malignancy | 4.12 | 1.46–11.58 | 0.007 | 4.41 | 1.64–11.90 | 0.003 |
Septic shock | 14.53 | 6.97–30.32 | <0.001 | 15.64 | 7.08–34.55 | <0.001 |
Delayed CVC removal (>72 hours) | 2.95 | 1.24–7.03 | 0.015 | 2.13 | 1.01–4.52 | 0.049 |
Breakthrough candidemia | 4.92 | 1.68–14.48 | 0.004 | 2.57 | 0.65–10.13 | 0.177 |
Delayed effective antifungal agents (>48 hours) | 1.93 | 0.93–2.23 | 0.881 | 1.01 | 0.52–1.98 | 0.797 |
Final antifungal therapy | ||||||
Fluconazole/Voriconazole | 1 | (reference) | 1 | (reference) | ||
Amphotericin B | 1.58 | 0.64–3.88 | 0.323 | 1.29 | 0.55–2.99 | 0.556 |
Echinocandin-based regimen | 1.04 | 0.42–2.64 | 0.921 | 1.47 | 0.59–3.64 | 0.407 |
Combination regimens | 1.26 | 0.78–4.74 | 0.375 | 11.26 | 1.21–105.2 | 0.034 |
Pathogens | ||||||
Candida albicans | 1 | (reference) | 1 | (reference) | ||
Non-albicans Candida spp. | 1.14 | 0.68–1.93 | 0.622 | 1.07 | 0.49–2.32 | 0.868 |
Uncommon Candida spp. | 1.40 | 0.69–2.85 | 0.354 | 1.40 | 0.59–2.78 | 0.983 |
Case periods | ||||||
2003–2008 | 0.99 | 0.52–1.87 | 0.97 | |||
2007–2011 | 1.78 | 0.56–2.09 | 0.82 | |||
2012–2015s | 1 | (reference) | ||||
