Table 3 Characteristics of uterine leiomyoma patients and results from negative binomial and Poisson models for MED12-mutation-positive and –negative leiomyomas, respectively.
From: Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas
Patient characteristics | Median (IQR)/n (%) N = 244 | NB model for number of MED12-mutation-positive leiomyomas (n = 241) | Poisson model for number of MED12-mutation-negative leiomyomas (n = 241) | ||
|---|---|---|---|---|---|
Multivariable-adjusted regression coefficient [95% CI] | P | Multivariable-adjusted regression coefficient [95% CI] | P | ||
Age at hysterectomy (y) | 49 (45–54) | 0.017 [−0.011, 0.046] | 0.22 | 0.020 [−0.0099, 0.050] | 0.19 |
Menopausal status | |||||
premenopausal | 178 (73.0) | reference | 1 | reference | 1 |
current use of HT | 33 (13.5) | −0.16 [−0.67, 0.36] | 0.54 | −0.41 [−1.01, 0.15] | 0.17 |
postmenopausal, no HT | 33 (13.5) | −0.85 [−1.49, −0.22] | 0.0080 | −0.49 [−1.18, 0.16] | 0.15 |
Parity | 2 (0–2) | −0.23 [−0.35, −0.10] | 0.00017 | 0.069 [−0.054, 0.19] | 0.26 |
Infertility | 22 (9.0) | 0.092 [−0.38, 0.59] | 0.71 | −0.18 [−0.83, 0.37] | 0.54 |
Use of oral contraceptives (never/ever) | 122 (50.0) | −0.040 [−0.34, 0.26] | 0.78 | 0.015 [−0.31, 0.34] | 0.93 |
History of PID | 11 (4.5) | −0.17 [−0.87, 0.57] | 0.63 | 1.05 [0.46, 1.59] | 0.00024 |
History of chlamydia | 10 (4.1) | −0.75 [−1.58, 0.075] | 0.076 | −0.12 [−0.97, 0.58] | 0.75 |
Prior myomectomy | 24 (9.8) | 0.41 [−0.045, 0.88] | 0.075 | −0.41 [−1.14, 0.20] | 0.22 |
Family history of leiomyomas | 38 (15.6) | 0.32 [−0.051, 0.71] | 0.091 | 0.061 [−0.39, 0.47] | 0.78 |
Hypertension | 59 (24.2) | 0.024 [−0.35, 0.40] | 0.90 | 0.20 [−0.19, 0.58] | 0.31 |
Diabetes mellitus | 16 (6.6) | −0.13 [−0.75, 0.51] | 0.69 | 0.29 [−0.36, 0.87] | 0.35 |
Thyroid disease | 24 (9.8) | −0.21 [−0.70, 0.30] | 0.40 | −0.16 [−0.78, 0.39] | 0.60 |
Body mass index (kg/m2)1 | 25.6 (23.1–29.8) | 0.0052 [−0.027, 0.037] | 0.74 | 0.0090 [−0.025, 0.043] | 0.60 |
Smoker (never/ever)2 | 63 (26.1) | 0.17 [−0.15, 0.49] | 0.30 | −0.016 [−0.38, 0.33] | 0.93 |
