Figure 2
The methylation and the mRNA expression changes of IRF8 affect the activity of VKH patients. (A) DCs from inactive and active VKH patients were cultured and collected to detect the expression of IRF8 with real-time PCR (n = 10, *p < 0.05). The methylation changes shown in CpG_1 (B), CpG_7.8 (C) and CpG_16 (D) of inactive VKH patients were notably lower than active patients (n = 10, **p < 0.01, ***p < 0.001). The data are shown as mean ± SEM. Unpaired t test was used to compare the mRNA level and methylation changes between two groups.
