Table 1 Methylation levels of IRF8 promoter in DCs from VKH patients versus normal controls.

From: Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease

CpG site

VKH Methylation level (%, mean ± SD)

NC Methylation level (%, mean ± SD)

p value

CpG_1

6.30 ± 2.86

4.28 ± 2.88

0.0189*

CpG_3

5.75 ± 1.52

5.68 ± 1.99

0.8994

CpG_4, 5, 6

6.29 ± 2.45

5.43 ± 4.45

0.4474

CpG_7,8

24.35 ± 9.16

20.10 ± 4.00

0.0321*

CpG_9,10

10.85 ± 3.39

11.65 ± 3.69

0.4517

CpG_11,12,13

7.29 ± 2.59

7.33 ± 2.92

0.8624

CpG_14

3.23 ± 2.86

2.82 ± 1.90

0.5598

CpG_15

5.60 ± 9.09

1.96 ± 3.89

0.0727

CpG_16

8.80 ± 4.13

5.32 ± 4.02

0.0044*

  1. VKH patients (n = 20, M:F = 14:6); Age (years: mean ± SD): 38.85 ± 11.47.
  2. Normal control (n = 30, M:F = 21:9); Age (years: mean ± SD): 38.99 ± 11.04.
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