Figure 1

In vitro differentiation protocol. Undifferentiated iMuSCs were cultured in Neural Stem Cell (NSC) Medium in suspension for 7 days to induce neurosphere formation. For myotube differentiation, neurospheres were plated on collagen-coated wells in Muscle Differentiation (MD) Medium. For neural differentiation, neurospheres were plated on laminin/poly-L-ornithine coated wells and cultured for 21 days in Neural Differentiation (ND3) Medium.