Figure 8
From: Dysregulation of Blimp1 transcriptional repressor unleashes p130Cas/ErbB2 breast cancer invasion
Graphical summary of the molecular mechanism leading to p130Cas/ErbB2/Blimp1 cell invasion. (A) In MCF10A.B2, the activation of ErbB2, in the absence of p130Cas overexpression, is not sufficient to increase Erk1/2 MAPKs activation and lower miR-23b expression to a threshold level that allows Blimp1 expression to occur (left panel). By contrast, ErbB2 activation and concomitant p130Cas overexpression strongly enhance Erk1/2 MAPKs activation and miR-23b promoter methylation, resulting in increased Blimp1 expression and, in turn, cell invasion (right panel).
