Figure 2 | Scientific Reports

Figure 2

From: NKG2D+CD4+ T Cells Kill Regulatory T Cells in a NKG2D-NKG2D Ligand- Dependent Manner in Systemic Lupus Erythematosus

Figure 2

Inverse correlation between the frequencies of NKG2D-expressing CD4+ T cells and Treg cells in both SLE patients and MRL/lpr mice. (A) Correlation analysis of the frequencies of NKG2D+CD4+ T cells and T cell subsets and B cells in SLE patients (n = 66). The correlation coefficient and P value are indicated. (B) Representative and statistical data of the frequency or cell numbers of Tregs and NKG2D+CD4+ T cells in splenocytes from B6.MRL/lpr mice, NZBW/F1 mice and C57L/B6 control mice (B6). Data represent three independent experiments with 3–5 mice each. Numbers represent percentages. Horizontal lines with bars show the mean ± SD. *** P < 0.001. (C) Correlation analysis of the frequencies of NKG2D+CD4+ T cells and T cell subsets and B cells in B6.MRL/lpr mice. The correlation coefficient and P value are indicated.

Back to article page