Figure 4 | Scientific Reports

Figure 4

From: Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Figure 4

Western blotting results of cyclin B1, survivin, Cx43, caspase-3, PARP and caspase-8 in four colorectal cancer cell lines, HCT106, HCT116, LoVo, and CT26, which were treated with different combinations of drugs. β-Actin or GAPDH was used as a loading control. The numbers represent different treatment groups: 1: control; 2: Taxol; 3: KLT; 4: Taxol+KLT; 5: Taxol&KLT; and 6: KLT+Taxol. (A) Cyclin B1 expression in the four cell lines; (B) Survivin expression in the four cell lines; (C) Cx43 expression in the four cell lines; (D) Cleavage of caspase-3 in the four cell lines; (E) Cleavage of PARP in the four cell lines; (F) Cleavage of caspase-8 in the four cell lines; (G–J) The densitometric analysis bar diagram of the results. Columns represent the mean from three independent experiments and bars represent standard deviations. These combinations are defined in “Kanglaite and Taxol treatment”. (G) HCT106; (H) HCT116; (I) LoVo; (J) CT26.

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