Figure 2 | Scientific Reports

Figure 2

From: Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice

Figure 2

Morphometric analyses of cytoarchitecture in single muscle fibers from young DesR349P mice using SHG microscopy. (a) Representative SHG images from the middle section of a single fiber from a wt (Deswt/wt), het (DesR349P/wt) and hom (DesR349P/R349P) knock-in mouse. Hom muscle fibers show prominent disruptions of the myofibrillar lattice. This is analyzed in detail in (b) for the number of verniers (VD), and in (c) for the cosine angle sums (CAS). VD and CAS were significantly increased and decreased, respectively, in single fibers from different muscles examined (SOL, EDL, IO) in hom mice. Het mice showed values similar to the wt. (n/m) denotes n fibers from m animals. *p < 0.05, one-way ANOVA with post-hoc Bonferroni-correction. Scale bar: 20 µm.

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