Table 2 Frequencies of malaria-resistant alleles by time period in nine selected genes and 224 available ancient European genomes.
From: Malaria was a weak selective force in ancient Europeans
FCGR2B | TIRAP | GRK5 | IL-10 | ATP2B4 | MARVELD3 | ABO | |||
|---|---|---|---|---|---|---|---|---|---|
rs1050501 | rs8177374 | rs2230345 | rs1800890 | rs4951074 | rs10900585 | rs2334880 | rs8176746 | rs8176719 | |
UPPER PALEOLITHIC | TT = 7 | CC = 6 CT = 3 | AA = 10 A* = 1 | AA = 1 TA = 2 TT = 1 | GG = 12 GA = 2 | TT = 12 GT = 2 | GG = 5 AG = 9 G* = 7 | GG = 8 G* = 9 | – = 3 -G = 2 GG = 1 |
EARLY NEOLITHIC | TT = 10 T* = 1 | CC = 3 CT = 8 TT = 1 T* = 2 | AA = 13 A* = 2 | AA = 2 TA = 2 TT = 1 | GG = 17 GA = 1 | TT = 13 T* = 2 | GA = 1 GG = 16 A* = 3 | GG = 24 G* = 12 | – = 2 GG = 3 -G = 3 |
MIDDLE NEOLITHIC | TT = 1 T* = 1 | TT = 1 C* = 2 | AA = 3 A* = 2 | TA = 1 | GG = 5 GA = 1 | TT = 4 GT = 2 T* = 4 G* = 1 | GG = 4 G* = 2 A* = 1 | GG = 4 G* = 8 | – = 2 |
LATE NEOLITHIC | TT = 3 T* = 1 | CC = 2 TT = 1 C* = 1 | AA = 5 A* = 2 | TA = 1 | GG = 6 | TT = 5 G* = 4 T* = 8 | GG = 6 G* = 1 | GG = 5 G* = 14 T* = 1 | – = 2 GG = 1 -G = 2 |
BRONZE AGE | TT = 24 TC = 1 | CC = 15 CT = 3 TT = 1 C* = 1 | AA = 19 A* = 2 | AA = 1 TA = 4 TT = 4 | GG = 20 GA = 4 | TT = 23 GT = 1 T* = 10 G* = 5 | GG = 16 GA = 5 AA = 1 | GG = 21 GT = 1 G* = 6 | –* = 4 GG = 4 |
IRON AGE | TT = 7 | CC = 5 | AA = 4 AT = 1 | AA = 2, TT = 3 | GG = 6 GA = 1 | TT = 5 G* = 1,T* = 1 | GG = 6 G* = 1 A* = 1 | GG = 6 G* = 1 | – = 3 GG = 1 -G = 1 |
ROMAN | TT = 2 | CC = 2 CT = 1 | AA = 5 | TT = 3 | GG = 5 | TT = 5 | GG = 5 | GG = 5 | – = 1 |
POST-ROMAN | TT = 2 CT = 1 | CC = 2 CT = 4 | AA = 6 | TA = 3 TT = 2 | GG = 8 | TT = 8 | GG = 7 GA = 1 | GG = 8 | – = 1 GG = 2 -G = 2 |
ANCIENT POPULATIONS | T = 98% C = 2% | C = 76% T = 24% | A = 99% T = 1% | C = 40%, T = 60% | G = 95% A = 5% | G = 8% T = 92% | G = 90% A = 10% | G = 99% T = 1% | - = 57,5% G = 42,5% |
GLOBAL EUROPEAN | EUR:T = 86%,T = 14% | EUR:C = 81%,T = 19% | EUR:A = 99%,T = 1% | EUR:A = 63%,T = 37% | EUR:G = 90%,A = 10% | EUR:T = 90%,G = 10% | EUR:G = 84%,A = 16% | EUR:G = 92%,T = 8% | EUR:- = 61%, G = 39% |
