Figure 4
From: The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
Molecular modeling of the peptide LHSPW in the active site of pAPN. (A) Structure of pAPN complexed with the modeled LHSPW peptide (green) depicting the pAPN ectodomain and its four components: head (cyan), neck (brown), body (in magenta), and tail (in yellow). For the modeling of peptide LHSPW in the active site of APN, two crystal structures were used: (B) the first three residues (Leu1-His2-Ser3) were modeled from the structure of pAPN complexed with polyalanines (PDB ID: 4NAQ), and (C) last two residues (Pro4-Trp5) were from the structure of pAPN complexed with substance P, which also contains a proline at the 4th position (PDB ID: 4HOM).
