Table 1 List of Aminopeptidase N inhibitor peptides.
From: The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach
Peptide | IC50 (µM) | Peptide | Ki (µM) |
|---|---|---|---|
Bestatin | 3.7 ± 0.4 | cyc-LHSPW | 24.7 ± 1.4 |
nHSPW | 6.5 ± 0.5 | cyc-LHSP | 121.4 ± 21.4 |
AHSPW | 9.4 ± 1.1 | cyc-LHS | >500 |
LHSPW | 10.6 ± 1.2 | cyc-PHSPW | >500 |
HSPW | 43.3 ± 3.9 | cyc-AHSPW | >500 |
PHSPW | 82.5 ± 9.3 | cyc-nHSPW | >500 |
EHSPW | 115.4 ± 17.2 | ||
nDQIY | >500 | For-HSPW | >500 |
LDSTF | >500 | Suc-HSPW | >500 |
DSTF | >500 | Cbz-HSPW | >500 |
ADARK | >500 | Ac-HSPW | >500 |
DARK | >500 | For-LHSPW | >500 |
INDFL | >500 | Suc-LHSPW | >500 |
AHLFN | >500 | Cbz-LHSPW | >500 |
FSLSK | >500 | Ac-LHSPW | >500 |
SKSGQ | >500 | ||
AHSTF | >500 | cyc-LDSTF | >500 |
FYLRE | >500 | cyc-ADARK | >500 |
FDWWG | >500 | ||
RDLVD | >500 | ||
EPKVA | >500 |
