Figure 7 | Scientific Reports

Figure 7

From: Construction of a highly efficient CRISPR/Cas9-mediated duck enteritis virus-based vaccine against H5N1 avian influenza virus and duck Tembusu virus infection

Figure 7

C-KCE-HA/PrM-E protection against HPAIV H5N1 challenge. Ducks were inoculated subcutaneously with 105 PFU of C-KCE-HA/PrM-E, 105 PFU of C-KCE, or PBS (n = 10 per group) as a control, following which they were intramuscularly challenged with 100-fold duck lethal dose (DLD)50 XN/07 at 2 weeks (A) or 4 weeks (B) pv, respectively. The ducks were observed daily for 2 weeks following influenza virus challenge.

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