Figure 1

Immunohistochemical staining of the temporal lobe of GRN mutation cases with antibody to phosphorylated TDP-43. Numerous neuronal cytoplasmic inclusions (arrows) and dystrophic neurites (arrowheads) were stained with anti-TDP-43-pS409/410 antibody in cases 1 (A), 2 (B), 3 (C) and 4 (D). The sections were counterstained with hematoxylin. The scale bar in (A) applies to all photomicrographs (100 μm).