Figure 3

Immunohistochemical staining of phosphorylated α-synuclein in the temporal lobe of the GRN mutation cases. Phosphorylated α-synuclein -positive structures were observed in the inferior temporal cortex (A), superior temporal cortex (B) and tuberomammillary nucleus (C) in case 4, and in the temporal cortex in case 1 (D), case 2 (E) and case 3 (F). Sections were counterstained with Kernechtrot stain solution. The scale bar in (A) applies to (C–F) (200 μm). The scale bars in (B), in insert (A,C and D–F) are 50 μm.