Figure 4

Immunohistochemical staining of amyloid β in the temporal lobe of GRN mutation cases. Amyloid β (Aβ) was observed in cases 1 (A), 3 (C) and 4 (D), but not in case 2 (B). Most Aβ-positive structures consisted of diffuse plaques. The scale bar in (A) applies to all photomicrographs (1.0 mm) and the scale bar in insert A applies to insert (B–D) (250 μm).