Table 2 Summary of immunohistochemical analyses of the initial study (Study A, No. 1–7).

From: Accumulation of multiple neurodegenerative disease-related proteins in familial frontotemporal lobar degeneration associated with granulin mutation

Case No.

Case

Age

TDP-43

Tau

Tau (neuronal/glial)

α-syn

Hip-Ent

Amygdala

Temporal

Frontal

Hip-Ent

Amygdala

Temporal

1

GRN mutation

54

FTLD-TDP (Type A)

A

IV

+++/+

++/+

+/+

+/+

++

+

+

2

56

0

IV

+++/++

+++/++

+++/++

++/++

+

N.A.

+

3

72

C

V

+++/+

++/+

+++/++

+++/-

N.A.

+

+

4

55

A

IV

+++/+

+/+

+/+

+/+

+++

+

++

5

Control

73

Negative

B

IV

++/−

++/+

++/+

N.A.

+

+

6

76

A

I

+/−

+/−

+/−

N.A.

+

+

7

79

A

I

++/−

+/+

+/+

N.A.

+

+

  1. +mild, ++moderate, +++severe, −negative, N.A.: not available.