Table 1 Comparison of clinical characteristics, chemokine levels, and contents of treatment between in survivors and dead.

From: Chemokine profiles of interstitial pneumonia in patients with dermatomyositis: a case control study

Characteristics

Dead (n = 6)

Alive (n = 24)

P

Age, years

64.5 (50–78)

59 (24–84)

0.604

Female, n (%)

3 (50)

16 (67)

0.641

CADM, n (%)

6 (100)

13 (54)

0.196

A/SIP, n (%)

6 (100)

16 (67)

0.155

Disease duration, months

2.2 (1–3.1)

1.6 (0.1–32.9)

0.586

Positive anti-MDA5ab, n (%)

4 (67)

4 (17)

0.029*

Positive anti-ARS ab, n (%)

1 (17)

10 (45)a

0.062

CK, IU/l

213 (43–721)

111 (23–5330)

0.678

ALD, IU/l

10.7 (5.2–11.6)

8.0 (3.1–94.6)

0.641

LDH, IU/l

376.5 (272–509)

324 (153–711)

0.421

CRP, mg/dl

0.91 (0.48–2.85)

0.41 (0.03–14.5)

0.422

KL-6, U/ml

1780 (501–3898)

626 (137–4508)

0.066

Ferritin, ng/ml

1056.5 (123–1611)

235.2 (15–23272.5)a

0.056

CXCL9, pg/mL

1968.8 (360.7–4053.3)

474.2 (125.3–9559.5)

0.272

CXCL10, pg/ml

275.3 (222.7–1470.8)

209.8 (17.4–1415.6)

0.17

CXCL11, pg/mL

261.9 (45.7–1930.1)

135.1 (2.19–636.4)

0.312

CCL2, pg/mL

1655.7 (893.7–4642.8)

608.5 (193.2–3075.1)

0.007*

CCL17, pg/mL

503.5 (138.0–1421.2)

574.4 (156.4–12747.4)

0.337

P/F ration, torr

289.3 (215.8–320.5)

382.1 (222.1–495.7)

0.002*

%VC, %

80.5 (48.1–103.4)b

82.6 (52.1–120.6)c

0.776

%DLco, %

39.9 (15.3–80.2)b

47.9 (11.74–104.8)c

0.903

Total GGO score

15.7 (8.3–18.7)

9.3 (3.7–18.3)

0.035*

Total fibosis score

4.85 (1.3–5)

3.3 (2–5)

0.229

PDN (n = 30), mg/day

57.5 (35–80)

50 (20–80)

0.297

CSA (n = 18), mg/day

225 (200–325)d

225 (175–325)e

0.735

TAC (n = 12), mg/day

 

4.5 (2.5–12.0)e

 

MPDN pulse, n (%)

3 (50)

3 (13)

0.075

Total IVCY (n = 17), mg

2050 (500–4900)d

1300 (200–7000)f

0.513

IVIG, n (%)

4 (67)

3 (13)

0.016*

Dead due to other factors (n = 5) Four died due to infections and 1 died due to TTP

  1. The laboratory markers are presented as the median (interquartle range). The P-values were estimated using Fisher’s exact test or Mann-Whitney U- test. *P < 0.05. Dead: dead due to interstitial pneumonia; CADM: clinically amyopathic dermatomyositis; A/SIP: acute/subacute interstitial pneumonia; MDA5: melanoma differentiation-associated gene 5; ARS: aminoacyl-tRNA synthetase; ab: antibody; CK: creatine kinase; ALD: aldolase; LDH: lactate dehydrogenase; CRP: C-reactive protein; KL-6: Krebs von den Lungen-6; CXCL: C-X-C motif chemokine ligand; CCL: C-C motif chemokine ligand; P/F: PaO2/FiO2; VC: Vital capacity; DLco: diffusion capacity of the lung for carbon monoxide; GGO: ground-glass opacity; PDN: prednisolone; CSA: cyclosporine; TAC: tacrolimus; MPDN pulse: methylprednisolone pulse therapy; IVCY: intravenous pulse cyclophosphamide; IVIg: intravenous immunoglobulin; TTP: thrombotic thrombocytopenic purpura. aNumber of subjects, n = 23. bNumber of subjects, n = 4. cNumber of subjects, n = 19. dNumber of subjects, n = 6. eNumber of subjects, n = 12. fNumber of subjects, n = 11.
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