Table 4 Multiple mutations driving 10 antigenic drifts for H3N2 influenza viruses inferred by JRFR.

From: Predicting influenza antigenicity from Hemagglutintin sequence data based on a joint random forest method

Antigenic drift events

Combination of mutations

HK68-EN72

S193N-G144D

EN72-VI75

N53D-S193D-S145N

VI75-TX77

S137G

TX77-BK79

D144V-N2K

BK79-SI87

Y155H-K189R

SI87-BE89

N145K, N145K-G135E, N145K-N193S

BE89-BE92

K145N-E156K-R189S, K145N-E156K-T262N-R189S, K145N-E156K-S133D-R189S

BE92-WU95

K135T-N145K-L226V, K135T-N145K-N262S

WU95-SY97

V196A-N276K-E158K-K156Q, V196A-N276K-E158K-K156Q-K62E

SY97-FU02

A131T-H155T-V202I

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