Figure 3 | Scientific Reports

Figure 3

From: Adipocyte Fatty-Acid Binding Protein is Overexpressed in Cirrhosis and Correlates with Clinical Outcomes

Figure 3

Hepatic gene expression of A-FABP4 and L-FABP1 in patients with decompensated cirrhosis, hepatic A-FABP4 expression in experimental model of acute-on-chronic liver injury and liver cells populations, and immunohistochemistry of A-FABP4 in human liver tissue. Panels a show relative hepatic expression, expressed as fold change, of adipocyte fatty-acid binding protein 4 (A-FABP4) in biopsies of patients with decompensated cirrhosis (n = 12) and ACLF (n = 10). Panel c shows hepatic expression of A-FABP in the whole liver of experimental models of chronic and acute on chronic liver injury (CCl4 and CCL4 + LPS). Panel d shows the expression of A-FABP4 in different liver cells populations in acute on chronic liver injury experimental model (CCL4 + LPS). Panel e shows A-FABP4 staining in liver tissue from a healthy subject, a patient with decompensated cirrhosis and a patient with ACLF. All photos show positive staining for liver macrophages.

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