Figure 4 | Scientific Reports

Figure 4

From: Methylglyoxal-induced glycation changes adipose tissue vascular architecture, flow and expansion, leading to insulin resistance

Figure 4

Glycation impairs pEAT insulin signalling in high-fat diet-fed rats. Insulin signalling in pEAT was evaluated through WB quantification of activated and total forms of IR (A) and Akt (B). pEAT metabolism was assessed by WB quantification of PPARgamma and Perilipin-A levels (C). Ct - Wistar 12 m; MG - Wistar + MG supplementation; HFD - HF diet-fed Wistar; HFDMG - HF diet-fed Wistar + MG supplementation; GK - Goto-Kakizaki 12 m.Bars represent means ± SEM, n = 6–8.* vs Ct; # vs MG; 1 symbol p < 0.05; 2 symbols p < 0.01.

Back to article page