Table 1 Results of APOE convergent deleterious predicted SNPs analyzed by 16 prediction tools classified in four different groups.

SNP rs ^#	Amino Acid Change^a	ValidationMethod^b	Sequence-Based^c				SLM-Based^c				Consensus-Based^c				Structure-Based^c
SNP rs ^#	Amino Acid Change^a	ValidationMethod^b	SIFT	Provean	Mutation Assessor	Panther	MutPred	EFIN	SNAP	SuSPect	Condel	MetaSNP	PON-P2	Predict SNP	PolyPhen	SDM	Fold-X	PoPMuSiC
rs11083750:C > A	Pro102Arg	Cluster	D	D	D	U	N	D	D	D	D	D	P	D	D	N	DT	DT
rs11542041:C > A	Arg132Ser	1000 G	D	D	D	D	D	D	D	D	N	D	P	D	D	D	DT	DT
rs7412:C > T	Arg176Cys	1000 G, cluster, freq.	D	D	D	D	D	D	D	D	D	D	N	D	D	N	DT	DT
rs557715042:G > T	Trp294Cys	1000 G, freq.	D	D	D	U	D	D	D	N	D	N	P	D	D	D	DT	DT

^aAPOE amino acid positions is relative to GenBank Accession number NP_000032.1.
^b1000G: SNP has been sequenced in the 1000 Genomes Project; freq.: Validated by frequency or genotype data: minor alleles observed in at least two chromosomes; cluster: Validated by multiple, independent submissions to the refSNP cluster.
^cN: Neutral; D: Deleterious; ST: Stabilizing; DT: Destabilizing; P: Pathogenic; U: Unknown.

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